Microglia, Pediatric Neurology, Autism Spectrum Disorder, Epilepsy, Neuroinflammation, Neurodevelopment Kaur, H. (2025) The Role of Microglia in Pediatric Neurological Disorders. Neuroscience and ...

When the researchers specifically deleted the Cx3cr1 gene from their C57BL/6J mice, they saw that plaque build-up ceased to occur after aspartame feeding. These results point to CX3CL1’s role in ...

This, in turn, upregulates CX3CL1, an immune signal that attracts inflammatory cells, exacerbating arterial plaque formation.” After 4 weeks of the aspartame diet, the mice started to develop ...

The researchers identified a signal molecule called CX3CL1 that became more active as insulin levels rose. Removing CX3CL1 receptors in the mice stopped the dangerous buildup of plaque in arteries – ...

In summary, our flow cytometric analysis reveals upregulation of markers for tissue residency and effector function of T cells specifically in the retina/RPE/choroid complex of Cx3cr1 mice. Aging of ...

During fibrosis, (myo)fibroblasts deposit large amounts of extracellular matrix proteins, thereby replacing healthy functional tissue. In liver fibrosis, this leads to the loss of hepatocyte function, ...

Together, these results suggest a unique trafficking capability of CD8 + CCR4 + T cells in patients with AS mediated by the upregulation of CCR1, CCR5, CX3CR1 and CD62L. Our study reports a CD8 + T ...