Following these screens, the researchers tested a third tool — a CRISPR-based demethylase (Tet1-dCas9). This enzyme removes methylation, a chemical mark that silences the maternal allele.

Introduction: Histone acetylation modifications can regulate gene transcription and play crucial roles in multiple tumorigeneses processes. YEATS domain proteins are one important type of acetylation ...

Researchers at Duke University and North Carolina State University have discovered a handful of new CRISPR-Cas systems that ...

Get Instant Summarized Text (Gist) New CRISPR-Cas systems have been identified, enhancing the gene editing toolkit. A notable system, SubCas9, from bacteria in dairy cows, is efficient, small, and ...

1 At conferences like Pittcon, where analytical chemistry and life science collide, CRISPR’s growing influence is unmistakable, taking a prominent place in the Bioanalytical & Life Sciences and ...

CRISPR is a technology that can be used to edit genes and, as such, will likely change the world. The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside a cell.

More information: Ryotaro Hashizume et al, Trisomic rescue via allele-specific multiple chromosome cleavage using CRISPR-Cas9 in trisomy 21 cells, PNAS Nexus (2025). DOI: 10.1093/pnasnexus/pgaf022 ...