Researchers at the University of California, Berkeley, boost the CRISPR/Cas9 system’s gene-editing success ... when paired with tiled catalytically inactive dCas9 molecules [which bind to DNA without ...

It's CRISPR, without the cut. The Horizon CRISPRi system uses a deactivated Cas9 nuclease (dCas9) fused to our proprietary SALL1-SDS3 repressor construct to block transcription of target genes, ...

Various strategies have been developed to enhance the imaging capabilities of CRISPR/Cas9. One approach involves fusing fluorescent proteins to deactivated Cas9 (dCas9), allowing for the ...

CRISPR is incredibly robust in terms of cutting DNA and targeting ... CRISPRa uses a version of Cas9 that is inactive (dCas9). It cannot cut DNA, but it progressively binds to targets using guide RNAs ...

"Our study is a first step in dramatically expanding our repertoire of effective and safe CRISPR-Cas9 enzymes. In our manuscript, we demonstrate the utility of these PAMmla-predicted enzymes to ...