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CRISPR-Cas9 Off-Target Effects: Challenges and SolutionsThe CRISPR-Cas9 system offers groundbreaking genome editing capabilities, yet off-target cleavage raises concerns about ...
Biomedical engineers at Duke University have demonstrated a promising new approach that could be used to treat a rare and ...
No doubt 2025 will usher in many more advances in CRISPR therapies, thanks to the FDA’s new Platform Technology Designation ...
CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...
Both Cas9 and Cas12a cleave DNA, but they differ in how they cut the molecule.
This manuscript describes a fundamental investigation of the functioning of Cas9 ... PAM recognition and underscores the importance of fine-tuning the flexibility of the PAM-interacting cleft as a key ...
Hossain and coworkers investigate the mechanisms of recognition of xCas9, a variant of Cas9 with expanded targeting capability ... why xCas9 exhibits improved recognition of the TGG PAM sequence ...
The emergent field of CRISPR/Cas sensing technology is showing promise as a new paradigm in clinical diagnostics, although widespread clinical adoption remains limited. This perspective paper ...
In the realm of genome editing, LNPs have emerged as a potent vehicle for delivering CRISPR/Cas components, offering significant advantages such as high in vivo efficacy. The incorporation of machine ...
The discovery of clustered regularly interspaced short palindromic repeats (CRISPR) DNA segments and CRISPR-associated proteins (Cas), known as CRISPR/Cas, has revolutionized biomedical research ...
Kennedy Jr. will divest his interests in several biopharma companies, including CRISPR Therapeutics and Dragonfly Therapeutics, if confirmed by the ...
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