The CRISPR-Cas9 system offers groundbreaking genome editing capabilities, yet off-target cleavage raises concerns about ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

No doubt 2025 will usher in many more advances in CRISPR therapies, thanks to the FDA’s new Platform Technology Designation ...

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

Researchers find a master epigenetic switch that activates silenced genes to compensate for their missing counterparts in a ...

This manuscript describes a fundamental investigation of the functioning of Cas9 ... PAM recognition and underscores the importance of fine-tuning the flexibility of the PAM-interacting cleft as a key ...

Pam Bondi is the first attorney in history to have been a lobbyist for foreign governments. She also just disbanded the FBI’s Foreign Influence Task Force. By Steve Benen There were quite a few ...

WASHINGTON – Moving swiftly to align the Justice Department with President Donald Trump’s agenda, Attorney General Pam Bondi on Wednesday issued a flurry of directives including the creation ...

Hossain and coworkers investigate the mechanisms of recognition of xCas9, a variant of Cas9 with expanded targeting capability ... why xCas9 exhibits improved recognition of the TGG PAM sequence ...

If you would still like them to be able to log in, you can pass the "nullok" option on the module's command line: If your system encrypts home directories until after your users entered their password ...