BACKGROUND: Dilated cardiomyopathy (DCM) is substantially influenced by genetic factors. Sarcomere function is intricately associated with other organelles, particularly the reciprocal regulation ...

† Department of Chemistry, Sogang University, Mapo-gu, Seoul 121-742, Republic of Korea ‡ Department of Nuclear Medicine, Cyclotron Research Center, Research Institute of Clinical Medicine, Chonbuk ...

Interference No. 106,115 was the second interference between UC and Broad over patent rights to CRISPR-Cas9 technology in eukaryotic cells. The first interference concluded in 2018 after an appeal ...

a personalized treatment to fix the baby's genome using what amounts to a pair of molecular scissors – the technique called Crispr-Cas9, which earned its creators the Nobel prize for chemistry in 2020 ...

At stake in the ongoing patent dispute over the gene-editing tool are rights to the most important new biotechnology of the age and credit for inventing it. The CRISPR patents are back in play.

The applications did not adequately show possession of an operable CRISPR-Cas9 system in eukaryotic cells, even though they described the core components of the technology. As a result ...

Systematic CRISPR screening with Cas12a and Cas9 systems identified 1236 genetic interactions ... pairs suggests that if a disruption in zinc homeostasis occurs due to the knockout of one transporter, ...

Baltimore, MD—New work led by Carnegie’s Phillip Cleves uses cutting-edge CRISPR/Cas9 genome editing tools to reveal a gene that’s critical to stony corals’ ability to build their reef architectures.

Researchers at the University of Minnesota have completed a first-in-human clinical trial testing a CRISPR/Cas9 gene-editing technique to help the immune system fight advanced gastrointestinal (GI) ...

(L) Western blot analysis of VHL CRISPR knockout in HepG2 cells using two gRNAs with indicated antibodies. ( M ) Cell growth of wild-type and VHL KO HepG2 over time monitored by Incucyte live cell ...