Systematic CRISPR screening with Cas12a and Cas9 systems identified 1236 genetic interactions ... pairs suggests that if a disruption in zinc homeostasis occurs due to the knockout of one transporter, ...

A successful CRISPR knockin isn’t just about inserting DNA. It’s about ensuring that edit stays functional and reliable over ...

Natural products (NPs), with their multi-target and multifaceted properties, present promising candidates for new drug development. This review delineates the anti-fibrotic pathways and targets of ...

Tools for diversifying genomic DNA in mammalian cells have long relied on base editors making C to T or A to G substitutions. Here, authors use RNA-guided DNA polymerases (EvolvR) to evolve ...