Novel precision genetic technologies such as CRISPR/Cas9 genome editing technology offer novel avenues to a better understanding the mechanisms of diseases. Using CRISPR/Cas9 we are able to precisely ...

researchers have utilized CRISPR-Cas9 gene editing in mice with a form of Fragile X Syndrome to alter gene expression, resulting in reduction of repetitive behaviors. Fragile X Syndrome (FXS) is ...

In 1989 Mario R. Capecchi, Martin Evans and Oliver Smithies created the first knockout mouse, which led to them winning the Nobel Prize in Physiology or Medicine in 2007 for their work. Genome editing ...

CRISPR/Cas9, a powerful genome ... Injection of the two vectors with increasing doses in newborn and adult knockout mice showed stable Factor IX activity at or above the normal levels over four ...

CRISPR construct to genetically ablate the GABA transporter GAT3 in the mouse visual cortex, with effects on population-level neuronal activity. This work is important, as it sheds light on how GAT3 ...

Researchers have developed a novel, noninvasive method of delivering CRISPR/Cas9 gene-editing technology into the brain – previously a challenge – to knock out a gene that causes anxiety.

CRISPR-Cas9 technology is used to knock out or modify DNA in research mice to study disease phenotypes and develop new treatments. CRISPR mice and rats are offered by Charles River, which uses ...

CRISPR KO mice/rats. To produce CRISPR/cas9-mediated gene indels to generate knock-out mice or rats. The investigator will provide or purchase the CRISPR gRNA(s). TGEF will inject gRNAs and cas9 into ...

A new method, which uses the CRISPR/Cas9 system to generate liver cancer mouse models by rapidly adding (knocking in) cancer genes to DNA, is being reported in the open access journal Genome Medicine.

A new study in mice demonstrates that a CRISPR/Cas9 gene-editing delivery system can bypass the blood–brain barrier to treat chronic anxiety.