Northwestern Medicine investigators have developed a new avenue to reprogram compromised immune cells to act against tumors, ...

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in ...

This changed with the development of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 genome editing ... system is the ‘gold standard’ of creating conditional knockout alleles ...

Methods We applied empagliflozin treatment to lupus-prone MRL/lpr mice to explore the renal protective potential of SGLT2 inhibitors. An SGLT2 knockout monoclonal podocyte cell line was generated ...

In this study, to provide an available donor pig for xenotransplantation research, we simultaneously targeted the porcine GGTA1, B2M, and CIITA genes by the CRISPR/Cas9 system and generated ... The ...

Endosomal recycling is a branch of intracellular membrane trafficking that retrieves endocytosed cargo proteins from early and late endosomes to prevent their degradatio ...

CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening ...

The preliminary data presented in this manuscript seem valuable. The data are currently incomplete and there are numerous technical concerns, some of which may arise from insufficient description of ...

For the first time, scientists have created a bi-paternal mouse – that is ... To address these limitations, the team used a CRISPR/Cas9-based gene editing technology to target 20 genes ...