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Genetically modified mice lacking PPDPF were developed using CRISPR-Cas9, and additional models were created through ... leading to reduced NAD⁺ levels. Mice lacking PPDPF (knockout) developed more ...

Methods: We established a mouse OC cell line model, PC53K, by transforming primary ovarian surface epithelial cells through CRISPR/Cas9-mediated TP53 knockout and simultaneous overexpression of human ...

Dsc2 KO and knock-in (KI) mouse models were generated using CRISPR/Cas9 technology on a C57BL/6J genetic background. Dsc2 KO mice were generated by deleting exon 4. KI mice were created by inserting ...

This study aims to uncover new therapeutic strategies for CCSA by utilizing a whole-genome CRISPR/Cas9 knock-out screen combined with functional ... We then corroborated those findings in a CCSA ...

In mice, both fasting and a high-fat diet (HFD ... followed by western blot analysis. The CRISPR/Cas9 system was utilized to generate Tet2 knockout cells. Lentiviruses were produced by co-transfecting ...

Researchers at Tel Aviv University have announced that they have successfully removed half of a tumor in a mouse's head using ... Aviv University was to use CRISPR-Cas9 to remove the protein ...

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

Mice with active infections had EcoHIV, the mouse equivalent of human HIV-1. Using CRISPR/Cas9, researchers were able to block replication of the virus and show they could potentially prevent ...

A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system ...