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CRISPR-Cas9 genome editing exploits the CRISPR-Cas ... Using a genome-wide CRISPR knock-out screen, the authors defined the repertoire of genes that are required for proerythroblast survival ...

Methods: We established a mouse OC cell line model, PC53K, by transforming primary ovarian surface epithelial cells through CRISPR/Cas9-mediated TP53 knockout and simultaneous overexpression of human ...

This study aims to uncover new therapeutic strategies for CCSA by utilizing a whole-genome CRISPR/Cas9 knock-out screen combined with functional ... We then corroborated those findings in a CCSA ...

Genome editing has advanced at a rapid pace with promising results for treating genetic conditions—but there is always room ...

Plant breeding plays a vital role in ensuring global food security by increasing crop yields, improving nutritional quality ...

Researchers at Tel Aviv University have announced that they have successfully removed half of a tumor in a mouse's head using ... Aviv University was to use CRISPR-Cas9 to remove the protein ...

Genome editing has advanced at a rapid pace with promising results for treating genetic conditions-but there is always room for improvement.

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

Researchers have developed a machine learning model that predicts Cas9 proteins that can be tailored with designer properties for therapeutic use.

Latest study leverages new constructs for nuclear localization signal (NLS) sequences to improve editing efficiency in human ...

Mice with active infections had EcoHIV, the mouse equivalent of human HIV-1. Using CRISPR/Cas9, researchers were able to block replication of the virus and show they could potentially prevent ...