Researchers at the Max Planck Institute for Evolutionary Anthropology have addressed a longstanding challenge in CRISPR ...

Genetic defects are exceedingly common, which is not surprising considering just how many cells make up our bodies, including our reproductive cells. While most of these defects have no or only ...

Nine years ago this month, researchers led by Harvard University’s David Liu reported on a new gene editing technique, a variation on CRISPR/Cas9 that they dubbed base ... creating unwanted mutations.

Since the initial development of CRISPR-Cas9, researchers have introduced more precise gene-editing techniques ... This precision reduces the risk of unintended mutations and is particularly useful ...

Scientists introduced CRISPR to the world as a gene ... treated are removed from the patient's body, then Cas9 tool is applied to correct the mutation — or actually, trigger production of ...

there is a heightened risk of off-target mutations in areas distinct from the original target of CRISPR/Cas9. Credit: S. Nakada In a new study published in the journal Nature Communications, ...

However, the CRISPR/Cas9 method can also result in unintended DNA mutations that may have negative ... researchers led by Osaka University introduced a novel technique called NICER, which is ...

However, the CRISPR/Cas9 method can also result in unintended DNA mutations that may have negative ... researchers led by Osaka University introduced a novel technique called NICER, which is ...

The risks of DNA deletions and unintended mutations must be considered and are an important aspect of the safety profile of such treatments. Once this is under control, a CRISPR-Cas9-driven ...

Using CRISPR-Cas9 gene editing, the research team introduced genetic mutations by cutting DNA in certain locations of the genome. They found that some of the variants they created had major impacts on ...

But modRNA introduced another issue, according to Lian. When modRNA Cas9 ... mutations in the genome by using a protein to change a single nucleotide instead of cutting both strands, like CRISPR ...

Just a year earlier, in 2012, she and microbiologist Emmanuelle Charpentier had published a landmark paper describing CRISPR-Cas9 ... after using CRISPR, the mutation responsible for causing ...