Africa is grappling with severe food insecurity in the wake of consecutive droughts, climate change, and ongoing conflicts, ...

This study presents an optimized CRISPR-Cas12a system for large-scale genetic screening, revealing critical genes involved in ...

A CRISPR-based system that erases itself from fly populations may offer a safer approach to tackling insecticide resistance ...

The CRISPR-Cas9 platform will be used to delete the ... The modified T cells will be multiplied in a lab before being re-introduced into the blood of each trial participant. The PD-1 checkpoint ...

such as CRISPR-Cas9, have enabled the precise development of synthetic microorganisms. These techniques are essential for minimizing off-target effects and non-specific mutations, ensuring safer ...

A genetic mutation in a metabolism-regulating hormone ... A new technology called CRISPR-Cas9 has emerged, developed in part in Church’s lab, that will test the limitations on human curiosity.

This manuscript describes a fundamental investigation of the functioning of Cas9 and in particular ... in the REC3 domain is due to the mutations incorporated in xCas9 or a result of binding ...

A temporally resolved CRISPR-Cas9 screen reveals DAC-induced DNA damage drives trans-cell cycle cytotoxicity that depends on ...

Researchers have revealed new details about the CRISPR-Cas5-HNH/Cascade complex, a variant of the type I-E CRISPR-Cas system, ...

CRISPR technology has radically transformed genetic research, and at the forefront of this transformation is CRISPR screening ...