Base and Prime Editing Offer Precision CRISPR-based systems that rely on traditional Cas nucleases like Cas9 cut through both strands of DNA which can lead to undesirable and even dangerous edits to ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

Scientists at the McGovern Institute and the Broad Institute of MIT and Harvard have reengineered a compact RNA-guided enzyme ...

CRISPR-Cas9 is a powerful gene editing system that has revolutionized our ability to treat disease and probe the human genome ...

While CRISPR ... of CRISPR-Cas9. This approach contrasts with the widely adopted strategy of incorporating terminally fused NLS sequences. The study evaluated the genome editing activity ...

we are excited to have these tools utilized by the community and also apply this framework to other properties and enzymes in the genome editing repertoire." CRISPR-Cas9 enzymes can be used to ...

A CRISPR treatment seems to have been effective for a baby’s devastating disease, but it is not clear whether such bespoke ...

The CRISPR-Cas9 patent landscape remains complex and unsettled. The Federal Circuit’s latest decision in University of California v.

transgene-free genome editing in plants using a miniature CRISPR system delivered by a common plant virus. Collaborating with CRISPR-Cas9 co-inventor Jennifer Doudna and Jill Banfield at UC ...