Base and Prime Editing Offer Precision CRISPR-based systems that rely on traditional Cas nucleases like Cas9 cut through both strands of DNA which can lead to undesirable and even dangerous edits to ...

Scientists at the McGovern Institute and the Broad Institute of MIT and Harvard have reengineered a compact RNA-guided enzyme ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

CRISPR-Cas9 is a powerful gene editing system that has revolutionized our ability to treat disease and probe the human genome ...

The only gene-editing therapy currently on the market is a CRISPR–Cas9-based treatment for two blood disorders, sickle-cell ...

A CRISPR treatment seems to have been effective for a baby’s devastating disease, but it is not clear whether such bespoke ...

The CRISPR-Cas9 patent landscape remains complex and unsettled. The Federal Circuit’s latest decision in University of California v.

While CRISPR ... of CRISPR-Cas9. This approach contrasts with the widely adopted strategy of incorporating terminally fused NLS sequences. The study evaluated the genome editing activity ...

transgene-free genome editing in plants using a miniature CRISPR system delivered by a common plant virus. Collaborating with CRISPR-Cas9 co-inventor Jennifer Doudna and Jill Banfield at UC ...