Scientists say study findings indicate that TC IV cells may represent a therapeutic target for the treatment of ...

T-cell-derived IFN-γ produced in the first days upon infection suppresses full differentiation of T FH cells. T-cell-derived IFN-γ is likely sensed by dendritic cells (DCs) rather than by CD4 + T ...

(Photo Credit: iStock/Getty Images) CD4 cells and CD8 cells are named after proteins on their surface: CD4 cells have a protein called cluster of differentiation ... cells called T cell lymphocytes.

NCOR1-deficient Treg cells failed to protect mice from severe weight loss and intestinal inflammation associated with CD4 + T cell transfer colitis ... NCOR1 for mouse and human regulatory T (Treg) ...

More information: Panpan Jiang et al, Dedicator of cytokinesis 8 (DOCK8) mutation impairs the differentiation of helper T cells by regulating the glycolytic pathway of CD4+ T cells, MedComm (2024).

The role of PD-1 in functional differentiation into Th1 and Th2 has been unclear. In murine naïve CD4 + T cell activation, we found that PD-1 stimulation during the early stage of T cell activation ...

Mechanistically, CD4+ T-cell LGMN impaired Treg differentiation and function by directly interacting with and facilitating the degradation of TRAF6 via chaperone-mediated autophagy, resulting in the ...

In a recent study published in EBioMedicine, a group of researchers determined the impact of nicotinamide mononucleotide (NMN) on Clusters of differentiation 4 + (CD4 +) Thymus cells (T cells ...

In a recent article published in the Cell Reports Journal, researchers used a preclinical mouse model to demonstrate that T helper 1 (Th1) effector memory cluster of differentiation 4 (CD4 ...

In the present study, we characterized how myosin-specific CD4 + T cells differentiate in the ... shape the local immune responses by promoting the differentiation of antigen-specific regulatory T ...