and excretion further highlight the intricacy of its metabolic pathways. Consequently, a deeper understanding of bilirubin metabolism not only elucidates the pathogenesis of liver and systemic ...

This review will place particular emphasis on alterations of bilirubin metabolism and transport that are important in the pathogenesis of hyperbilirubinemia. Bilirubin Synthesis Although ...

The liver plays a key role in bilirubin conjugation and excretion. Any disruption in this process - whether in the production, metabolism, or excretion of bilirubin - leads to conditions such as ...

The liver plays a key role in bilirubin conjugation and excretion. Any disruption in this process—whether in the production, metabolism, or excretion of bilirubin—leads to conditions such as ...

Jaundice is a symptom of an underlying condition that impairs the excretion of bilirubin from the body. As the 120-day lifespan of a red blood cell comes to an end or the cell becomes damaged ...

Truly asymptomatic elevated levels of conjugated bilirubin are less likely given that the most common causes usually generate symptoms: hepatocellular disease, impaired canalicular excretion ...

Other interventions are designed to limit bilirubin production, enhance its metabolism and excretion, or both (Table 1). Of these interventions, metalloporphyrin inhibition of heme oxygenase ...