A year later came another major breakthrough, as two groups described 2, 3 a novel gene-editing tool called CRISPR-Cas9 and demonstrated its use in eukaryotic cells. These two reports helped start ...

The BRILLIANCE study of EDIT-101 in Leber congenital amaurosis type 10 (LCA10) – an inherited form of blindness – was reported to be the first 'in vivo' CRISPR/Cas9 medicine to be administered ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas system to modify a genome in a targeted manner. Guided by RNA, the Cas9 endonuclease breaks DNA at a target sequence. Imprecise repair of the ...

When the CRISPR Cas9 protein is added to a cell along with a piece of guide RNA, the Cas9 protein hooks up with the guide RNA and then moves along the strands of DNA until it finds and binds to a ...

The recent discovery of CRISPR/Cas9 technology simplified engineering synthetic gene drives for diverse animal species. Nowadays, synthetic gene drives have been engineered in laboratory mosquitoes ...

Widely used as a genome editing tool, the CRISPR-Cas9 system allows researchers to precisely induce frameshift mutations in specific genes or insert foreign nucleic acid sequences into a cell’s DNA.

CRISPR-Cas9 based gene editing is a powerful tool which can induce heritable mutations at desired genomic loci without leaving transgenic trace in plants. Here we constructed a robust, multiplex ...

The method may allow researchers to edit more types of genetic mutations than existing genome-editing approaches such as CRISPR-Cas9, researchers report today (October 21) in Nature. Emma Haapaniemi, ...

In a recent study published in Science Advances, researchers reported using synthetic genomics and a clustered regularly interspaced short palindromic repeats-­associated protein 9 (CRISPR-Cas9 ...