The microtubule-associated protein XMAP215 promotes microtubule growth, but how this occurs has been unclear. To address this question, Gary Brouhard et al. developed a single-molecule ...

For decades microtubule-targeting agents (MTAs) have been a cornerstone of cancer treatment regimens and continue to be heavily employed as backbone chemotherapy in combination with new targeted ...

This study provides compelling evidence that kinesin's stepping mechanism is governed by strain-induced conformational changes in its nucleotide-binding pockets. Using pre-steady state kinetics and ...

Specifically, tau fragments containing the microtubule binding region and its adjacent C-terminal sequence wreaked havoc on synaptic plasticity when injected into rat brains. Scientists led by Michael ...