Cerebellar rhythm loss due to climbing fiber regression is a shared pathophysiology of motor deficits across cerebellar ...

Northwestern Medicine scientists have uncovered new insights into how neurofilaments act like Velcro in neurodegenerative ...

Neuronal atrophy early in a mouse model of spinal cerebellar ataxia 1 may represent an adaptive mechanism that restores the density of potassium channels in Purkinje neurons, thus normalizing ...

Huntington's disease is a rare genetic, autosomal dominant, neurodegenerative disease, caused by CAG repeat expansions in the HTT gene, that is polymorphic on the healthy allele and contains more than ...

Minoryx Therapeutics has dosed the first patient in its phase 2a TREE study, which evaluates the safety and efficacy of ...

So I think you've rightly keyed in on the fact that the next opportunities to generate capsid POC really sit with the Friedreich’s ataxia and ... into the brain of a mouse expressing human ...

Remember, ataxia telangiectasia ... It's kind of easy to do in rats and mice. But unless you're going to do a biopsy, it's quite difficult to do in a human. You can do it in the brain with ...

Mice treated with ASO exhibited substantial reductions in ataxin ... SCA7 is a rare disease characterized by progressive ataxia and visual loss caused by retinal degeneration with cone-rod dystrophy ...