UT Southwestern Medical Center scientists have identified a protein that appears to act as a master control switch for ...

The human brain contains about 86 billion neurons. These cells fire electrical signals that help the brain store memories and ...

Astrocytic glutamate uptake drives glycolysis and subsequent shuttling of lactate from astrocytes to neurons for oxidative metabolism. Astrocytes also convert synaptically reclaimed glutamate to ...

By providing an overview of metabolism at the system level ... The production of glutamine from glutamate was added to the astrocyte, and the conversion of GABA into glutamate was defined for both ...

[49] Glutamate excitotoxicity ... declared they have no competing interests. Astrocytes perform critical roles in amino acid, nutrient and ion metabolism in the brain, coupling of neuronal ...

Glutamate and nitric oxide form a feedback loop that sustains ... Transient anoxia induced a long-lasting Ca 2+ elevation in astrocytes that mirrored aLTP. Blocking astrocyte metabolism or depletion ...

Whereas glutamine metabolism is important for mitochondria, it is not for endogenous glutamate production ... to detect neurons and astrocytes, respectively. The statistical analysis showed that the ...

Today glia are known to help regulate metabolism ... functions is they were studying different astrocytes.” Using a technique that visualizes glutamate, the researchers observed the cells ...

“A deeper understanding of urea metabolism in reactive astrocytes may prove to be critical in understanding ... converting ornithine to putrescine rather than to its normal end product, glutamate. How ...

Intriguingly, the role of AMPK in the regulation of brain cell metabolism has been ... of pyruvate carboxylase (PC) in astrocytes. In addition, we demonstrate that AMPK activation leads to augmented ...

and clean up byproducts of brain cell metabolism. Rothstein’s team focused on a particular astrocyte protein, glutamate transporter-1, which previous studies suggested was lost from astrocytes in ...