Hosted on MSN3mon
Loosening chimeric antigen receptor's grip on T-regulatory cells improves function, researchers find
A new paper from MUSC Hollings Cancer Center researchers is helping to reveal the "rules" for engineering chimeric antigen receptor (CAR) Tregs. Tregs, or T-regulatory cells, have shown promise in ...
Medical Xpress1mon
News on antigens
A patient has achieved over 18 years of remission from neuroblastoma, a type of nerve cell cancer, following treatment with chimeric antigen receptor (CAR) T cell therapy and without requiring any ...
BioTechniques2y
Preparing the troops: cryo-EM image provides insight into T-cell activation
The research team hypothesized that binding of the antigen to the T-cell receptor would cause a conformational change, allowing it to initiate a downstream signaling cascade. By comparing an ...
Nature8y
Fully human CD19-specific chimeric antigen receptors for T-cell therapy
T-cell mediated immune responses specific for peptides from the murine scFv antigen-binding domain of ... potential for immunogenicity of synthetic receptors requires analysis of all foreign ...