Swiss pharma giant Roche says its new antibiotic zosurabalpin will progress to phase 3 testing. It’s the first drug in its ...

Researchers have created a pipeline for discovering unique combinations of molecules that increase the effectiveness of ...

A team led by Paul Hergenrother at the University of Illinois Urbana-Champaign has discovered a new antibiotic that exclusively targets gram-negative bacteria and avoids wiping out the ecosystem ...

Roche is planning to move a new antibiotic into late-stage clinical trials after studies showed it had potential to tackle a ...

Their discovery was challenging because most antibiotic targets are shared by both Gram-positive and Gram-negative bacteria. Since the gut microbiome contains many Gram-negative bacteria ...

All that said, when it comes to antibiotic resistance, gram-negative bacteria have an edge thanks to their double membranes. The outer membrane of gram-negative bacteria physically blocks some ...

Roche (RHHBY) is planning to move a new antibiotic into late stage clinical trials after early studies showed it had ...

These bacteria lacked typical antibiotic resistance genes and hadn't made spontaneous copies of genes that were protective as the gram-negative bacteria had. Instead, heteroresistance correlated ...

Infection control standards need to be followed closely to prevent the development and spread of antibiotic-resistant infections. Gram-negative bacteria have a hard, protective outer shell.

In it, the researchers describe how an imbalance in the three-part protein complex—MacAB-TolC—helps gram-negative bacteria resist antibiotics. The MacAB-TolC complex, known as a multidrug ...

Gram-positive bacteria show blue or purple after Gram-staining in a laboratory test. They have thick cell walls. Gram-negative bacteria show pink or red on staining and have thin walls. They ...