AI and biophysical modeling unite for novel protein design
An interdisciplinary research team from Leipzig University and the Saxon AI center ScaDS.AI has developed a novel approach ...
AI model generates antimicrobial peptide structures for screening against treatment-resistant microbes
A team of microbiologists, chemists and pharmaceutical specialists at Shandong University, Guangzhou Medical University, ...
AI used to design a multi-step enzyme that can digest some plastics
Unfortunately, there isn't an enzyme for many reactions we would sorely like to catalyze—things like digesting plastics or ...
eLife9d
Multi-omics investigation of spontaneous T2DM macaque reveals gut microbiota promote T2DM by up-regulating the absorption of excess palmitic acid
Although gut microbiota and lipid metabolites have been suggested to be closely associated with type 2 diabetes mellitus (T2DM), the interactions between gut microbiota, ...
C&EN19d
Semirational Engineering of a Distal Loop Region to Enhance the Catalytic Activity and Stability of Leucine Dehydrogenase
State Key Laboratory of Bioreactor Engineering East China University of Science and Technology 130 Meilong Road, Shanghai 200237, China Research Center for Systems Biosynthesis, China State Institute ...
Monash University21d
Molecular Homology
Source: LabXchange 2019 Molecular Homology compares DNA sequences and amino acid sequences between species to determine relatedness. This information can be represented as a phylogenetic tree that ...
Nature24d
Mass testing of mutant enzymes involved in photosynthesis
The unexpected finding of several single-point mutants with an improved affinity for CO 2 demonstrates that the relationship between the amino-acid sequence of rubisco and its enzymatic function ...
Frontiers27d
Annotation and characterization of immunoglobulin loci and CDR3 polymorphism in water buffalo (Bubalus bubalis)
Using Geneious software, the amino acid sequences of the V and J genes were aligned and structurally segmented. Based on the conserved amino acid motifs in the FRs and CDRs recognized by MiXCR, in ...
World Scientific28d
DNN-PPI: A LARGE-SCALE PREDICTION OF PROTEIN–PROTEIN INTERACTIONS BASED ON DEEP NEURAL NETWORKS
Institute of Intelligent Machine, Hefei Institutes of Physical Science, Chinese Academy of Sciences, HeFei City, AnHui Province 230031, P. R. China University of Science and Technology of China, HeFei ...