When the genetically altered mice were just 18-20 months old, the lack of ELOVL2 enzymatic activity decreased the expression of several genes related to B cell development ... "The same immune cell ...

The study is useful for advancing spatial transcriptomics through its novel regression-based linear model (glmSMA) that integrates single-cell RNA-seq with spatial reference atlases, though its ...

The data convincingly show that the transcription factor Sp1 regulates ephrin-mediated axon guidance in the spinal cord. Although the authors show that Sp1 and its co-activators p300 and CBP are ...

View software available in the Integrated Systems Biology and AI — Tailored Pharmacology and Precision Medicine Lab led by Hu ...

Researchers at the University of Colorado Anschutz Medical Campus have uncovered a critical, previously underappreciated role ...

Researchers have uncovered a critical, previously underappreciated role for B cells in vaccine protection. Best known for producing antibodies, B cells also guide other immune cells, specifically CD8 ...

CAR T-cell therapy, also known as Chimeric Antigen Receptor T-cell therapy, is a personalized form of immunotherapy treatment that genetically modifies a patient's immune system to target and ...

Fred Hutch and MSK researchers showed that tumors driven by hiccups in RNA processing can't hid from the immune system. In ...

Cardiac fibroblasts (CF) can become activated and produce excessive extracellular matrix, contributing to fibrotic remodeling ...

Background Muscle wasting and weakness (sarcopenia) are commonly associated with COPD causing frailty and reduced quality of ...