You may have seen it in the news recently: a baby in Pennsylvania with a rare genetic disorder was healed with a personalized ...

Thalassemia occurs when there is a mutation or deletion in the genes that code for these globin chains. Depending on which chain is affected, it is classified as: Alpha-thalassemia: Caused by ...

“A person normally inherits four alpha globin genes, two from each parent ... Multiplex Ligation-dependent Probe Amplification, which detects deletions or duplications in gene copies “These tests are ...

Researchers at the University of California, Davis, have deleted a cluster of genes in wheat that generates ... gamma radiation to target and delete alpha-gliadins, which can cause severe ...

Three common α-globin gene deletions, three mutations, and 17 mutations in the β-globin gene were detected using PCR-flow fluorescence hybridization. Next-generation sequencing (NGS) and CNVplex ...

We sought to evaluate the impact of alpha globin gene deletions on NO signaling and unexpectedly found human arteries use not only alpha but also beta globin to regulate eNOS. The eNOS-hemoglobin ...

We sought to evaluate the impact of alpha globin gene deletions on NO signaling and unexpectedly found human arteries use not only alpha but also beta globin to regulate eNOS. Hemoglobin is expressed ...

Nonhomologous end joining repair achieved fusion of the breakpoints and generated deletions that spanned ... mutations in the COL7A1 gene encoding the C7 alpha-1 chain, and C7 impairments can ...

The different types of thalassemia develop due to genetic mutations or deletions (where genetic code is missing) in the genes that support alpha and beta globin production. Abnormalities in these ...

Alpha-globin and beta-globin protein chains make up hemoglobin. Changes in the alpha- or beta-globin genes that provide instructions for these proteins can lead to thalassemia. Four genes comprise ...

Hemoglobin H Disease is a more severe form of alpha thalassemia caused by the deletion of three alpha globin genes (inherited from both parents). Individuals with hemoglobin H disease may experience ...