People with alpha-thalassemia have a deletion of one or more of their α globin-producing genes. (1 missing) alpha-thalassemia carrier You’re a silent carrier with no significant symptoms.

Alpha-thalassemia is caused most frequently by deletions involving one or both alpha globin genes and less commonly by nondeletional defects. A large number of alpha-thalassemia alleles have been ...

Without alpha globin, hemoglobin cannot carry oxygen ... Multiplex Ligation-dependent Probe Amplification, which detects deletions or duplications in gene copies "These tests are particularly ...

An increase in alpha-globin gene copy number was associated ... “The high frequency of the HBA gene deletion found in Black Americans may act to reduce the overall burden of kidney disease ...

It’s caused by either a genetic mutation or a deletion of certain ... that are more serious. In alpha thalassemia, at least one of the alpha globin genes has a mutation or abnormality.

The different types of thalassemia develop due to genetic mutations or deletions (where genetic code is missing) in the genes that support alpha and beta globin production. Abnormalities in these ...

Furthermore, three α-globin gene deletions involving severe nondeletional mutations (e.g., hemoglobin Constant Spring) can also cause the hemoglobin Bart's hydrops fetalis syndrome. With regard ...

Scientists have revealed an entirely new mechanism through which hemoglobin gene ... eIF2-alpha, and that phosphorylated eIF2-alpha is essential to form the machinery needed to splice globin ...