New findings suggest that reducing the variant allele frequency of JAK2V617F should be a goal of treatment for polycythemia ...

FORE Biotherapeutics Presents New Plixorafenib Results at AACR 2025 Demonstrating Pharmacodynamic Effect in Clinical Tumor Biopsies and Decreased V600E Mutant Allele Frequency in ctDNA of 85% of ...

accurately detects BRAF mutations in tumor biopsies and change in variant allele frequency (VAF) of BRAF mutation in ctDNA may be a surrogate marker for monitoring disease. The data is being ...

These situations are likely to lead to allele fixation or loss within a gene pool, thereby reducing the genetic diversity of the population's gene pool. Identify the impact of different evolutionary ...

Highly sensitive and accurate methods are needed to define target allele frequencies (AFs) in next-generation sequencing (NGS) reference material which is critical for the development and ...

ALFRED Revival is an open-source project to rebuild the allele frequency database created and hosted by the Kidd Lab at Yale University. Due to a lack of ongoing support for the project, the original ...

Understanding allele frequency is a fundamental concept in population genetics and evolutionary biology. It enables researchers to study how genes are dispersed within populations and how they change ...

In the world of genetics, understanding allele frequencies is essential for scientists and researchers. Allele frequencies provide insights into the diversity of a population and can help predict how ...

Identifying allele frequencies may aid in selecting the diagnostic method for alpha-1 antitrypsin deficiency (AATD), cystic fibrosis (CF), and other autosomal recessive diseases, as stated in a study ...

The frequencies and diversities of human leukocyte antigen (HLA ... DRB1*15:02 (7.54%); DRB1*07:01 (6.68%), DRB1*10:01 (6.63%), respectively, with the highest allele diversity level observed in locus ...

Each increase in %ctDNA decreases survival probability. In this study, we hypothesized that the dominant clone allele frequency (DCAF) on ctDNA in BTC would be associated with OS and progression-free ...

IMPRINTER: An open label, multicenter, dose escalation/expansion, phase 1 study of imu-201 (PD1-Vaxx), a B-cell immunotherapy as monotherapy or in combination with atezolizumab, in adults with ...