We have shown that obexelimab inhibits the phosphorylation of BTK, thereby interfering with BCR signalling. Objectives ... Furthermore, KEGG pathway analysis demonstrated key components of actin ...

BTK mediates signaling downstream of the B cell receptor (BCR), toll-like receptors (TLRs), and Fc receptors (FcRs), making it an attractive therapeutic target in antibody-mediated autoimmune and ...

Cells use the polymerization of actin alone to create some types of movement, but many other forms of movement require interplay between actin and an enzyme called myosin. Credit: extender_01 ...

More information: Kinga Szigeti et al, CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganization, eBioMedicine (2024). DOI: 10.1016/j.ebiom.

Through the actin cytoskeleton it drives adaptation to the mechanical properties of the tissue environment leading to an ability to invade previously immune restricted niches. Human genetic diversity ...

Antigen-induced B-cell receptor (BCR) signaling is critical for initiating and regulating B-cell activation. The actin cytoskeleton plays essential roles in BCR signaling. Upon encountering ...

The study provides novel insight into how B cells upon activation attenuate BCR signalling by contraction of the actin cytoskeleton and clustering of BCR foci and this dynamic response is mediated by ...

Steroid hormones, to which belong sex hormones like estrogen or testosterone, are important signaling molecules ... show that filamentous actin, a component of the cytoskeleton, interacts with ...

While extensive research has shed light on the signaling pathways in health and ... of BCR endocytic mechanisms and the role of the actin cytoskeleton and post-translational modifications in ...

Contact between BCRs and foreign invaders prompts B cells to make antibodies, and CD22 inhibits BCR signaling to keep B cells from inappropriately releasing antibodies. Interestingly, previous ...

BTK inhibition has proven effective in treating CLL and other B-cell lymphomas by targeting the B-cell receptor (BCR) signaling pathway. BCR signaling is key to both normal B-cell development and ...