To overcome these barriers, researchers explored lentiviral vectors, which integrate into the genome and bypass AAV-specific limitations. In the study, "Lentiviral Gene Therapy with CD34 ...

Organoids were cultured from healthy donor iPSC sources and differentiated using the human iPSC-derived Cerebral Organoid ...

The adeno-associated viral (AAV) vectors have not been exploited extensively partly due to inability to generate high titer helper free recombinant viruses. Furthermore, the size of the transgene ...

AAV vectors have a low immunogenicity profile ... They can infect both dividing and non-dividing cells and provide stable, long-term gene expression. Lentiviral vectors, derived from HIV-1, are widely ...

adeno-associated virus (AAV), retrovirus, or lentivirus, or non-viral platforms, such as lipid nanoparticles, to transport the chosen plasmids, cDNA, or RNA molecules. 2 However, not all vectors have ...

The most common method for evaluating replication competency of lentivirus and AAV vectors is through serial passaging of virus in cell culture lines and subsequent identification of viral particles ...

Gene therapy represents a paradigm shift in modern medicine, offering unprecedented opportunities to combat diseases at their ...

Researchers have demonstrated, for the first time in the world using mice, the ability to overcome significant challenges in ...

A new vector system known as lentiviral vectors can permanently integrate the gene into dividing and non-dividing cells. The capacity of lentiviral vectors to reliably integrate at various genomic ...

More recently, the Vector Development Laboratory merged with our group, and we have expanded our services to offer AAV, first-generation adenovirus (FGAd), helper-dependent adenovirus (HDAd), ...