While it is widely accepted as the primary binding site for Wnt ligands, alternative models suggest that co-receptors, such as LRP5/6, or the lipid bilayer environment, may modulate this interaction.

Get Instant Summarized Text (Gist) Both activation (agonism) and blockade (antagonism) of the GIP receptor reduce body weight and food intake, but through distinct brain mechanisms. GIPR agonists ...

Seven-transmembrane (7TM) receptors form the largest superfamily of cell-surface receptors. They respond to a wide range of stimulants including light, hormones, neurotransmitters, and odorants.

A protein that acts as a cannabinoid receptor and is present in the structure controlling exchanges between the bloodstream and the brain could be part of the answer, according to a study ...

To study how GLP-1 receptor agonists affect muscle and fat, the HKUMed research team used genetic data of more than 800,000 European participants from different genome-wide association studies (GWAS).

Sweet taste receptors in the heart: A new pathway for cardiac regulation New research shows that the heart can sense sweeteners and can increase the force of heart muscle contraction in response ...

Additionally, their research may explain why high consumption of artificially sweetened beverages is linked to arrhythmogenesis, or an irregular heartbeat. Not only are these sweet taste receptors ...

ROCKVILLE, MD – In a surprising discovery, scientists have found that the heart possesses "sweet taste" receptors, similar to those on our tongues, and that stimulating these receptors with ...

The GLP-1 receptor agonist exenatide failed to meet its primary outcome in a phase III trial of Parkinson's disease patients. The finding contrasts with positive results from previous phase II ...

Attribution (BY): Credit must be given to the creator. Extracellular signals perceived by 7-transmembrane (7TM)-spanning receptors initiate desensitization that involves the removal of these receptors ...

The discovery focuses on prostaglandin (PG) receptors in the uterus that enhance the critical process of decidualization, which is necessary for a successful pregnancy. This finding opens the door ...

STRIvE-02: A First-in-Human Phase I Study of Systemically Administered B7-H3 Chimeric Antigen Receptor T Cells for Patients With Relapsed/Refractory Solid Tumors Overall, 262 patients with ER+/HER2– ...