Worldwide, more than 55 million people suffer from dementia caused by Alzheimer's disease (AD) and other conditions that ...

Using advanced microscopes that capture brain cell anatomy and activity, a portion of a mouse's brain was mapped and rendered into a 3D atlas that creates new possibilities for neuroscience.

"In our investigation, we utilized transgenic mice that contain expression for five major amyloid pathologies that allow for rapid progression of AD and Aβ deposition known as 5xFAD mice," the ...

It has been shown that noninvasive optogenetic-driven 40 Hz stimulation promotes neural activity and attenuates pathology in the 5XFAD mouse model of Alzheimer’s disease. Findings from a new ...

Working with "5XFAD" mice, which genentically model Alzheimer's, Murdock and co-authors first replicated the lab's prior results that 40 Hz sensory stimulation increases 40 Hz neuronal activity in ...

Department of Geriatrics and Gerontology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, Taiwan Department of Public Health, College of ...

Background and Rationale: Recent Alzheimer’s disease (AD) studies with 5XFAD, a mouse model of Alzheimer’s disease, were mainly focused on cognitive functions. Here, to investigate the change of motor ...

The experiments were conducted in a specific mouse strain called the 5XFAD, which is used as a model for human Alzheimer's disease. The study is relevant to β-amyloid-associated Alzheimer's and ...

with JNPL3 (mice expressing the P301L mutation in tau). The 3xTg model consists of APP (Swedish mutation), PSEN1, and MAPT for investigation of both plaques and tangles, while the 5xFAD model ...

The scientists used a mouse model of Alzheimer’s disease called 5xFAD. The genetically modified mice were treated with hyperbaric oxygen therapy to see if they could halt or slow the disease ...

Using mass spectrometry, we have quantified the phosphoproteome of the CK‐p25, 5XFAD, and Tau P301S mouse models of neurodegeneration. We identified a shared response involving Siglec‐F which was ...

Interestingly, while TMEM59 overexpression had no effect on worsening synaptic defects and impaired memory in the 5xFAD mouse model of AD, it significantly exacerbated AD-like pathologies by ...