Species Differences. Gene-expression patterns cluster into distinct cellular groups in 5xFAD mouse (top) and human AD brains (bottom). [Courtesy of Zhou et al., Nature Medicine.] With the advent of ...

The researchers tested the compound in 5xFAD mice, a well-established model of Alzheimer’s disease, administering diAcCA for three months. The results were remarkable. Related Stories ・Common ...

To further test the hypothesis that this fundamental signaling pathway is a primary target of synapse degeneration in Alzheimer's disease, the Zou lab used 5XFAD mice, a well-known mouse model of ...

How did lack of FIRE affect plaque pathology? The scientists crossed FIRE mice with 5xFAD transgenic animals, then analyzed cortical, hippocampal, and thalamic tissue from 5-month-old offspring. They ...

Working with "5XFAD" mice, which genentically model Alzheimer's, Murdock and co-authors first replicated the lab's prior results that 40 Hz sensory stimulation increases 40 Hz neuronal activity in ...

"We chronically sleep-deprived wild-type mice and the 5xFAD mouse model of cerebral amyloidosis," Parhizhar wrote, describing the basics of the study, which led the team to make new discoveries ...

It has been shown that noninvasive optogenetic-driven 40 Hz stimulation promotes neural activity and attenuates pathology in the 5XFAD mouse model of Alzheimer’s disease. Findings from a new ...

Next, the investigators used mouse models of familial Alzheimer's disease (5xFAD) to study amyloid-beta plaque deposition. It is thought that amyloid-beta plaques disrupt normal cell function in ...