Most pharmacogenetic studies of the impact of ABCB1 variation on the pharmacodynamics of the SGAs have focused on three polymorphisms, 3435C/T (rs1045642), 2677G/T (rs2032582) and 1236C/T (rs1128503).

5-HT 3 receptor antagonist transporter genes: clinical resistance to 5-HT 3 antagonists is associated with SNPs (predominantly rs1045642, 3435C>T) in the gene that codes for the drug efflux ...

H. Chang et al., Association of the ABCB1 gene polymorphisms 2677G>T/A and 3435C>T with clinical outcomes of paclitaxel monotherapy in metastatic breast cancer patients. Ann. Oncol. 20, 272–277 (2009) ...

There is significant variability in the efficacy and safety of oral P2Y12 inhibitors, which are used to prevent ischemic outcomes in common diseases such as coronary and peripheral arterial disease ...

Vinblastine and its derivatives used in clinics as antitumor drugs often cause drug resistance and some serious side effects; thus, it is necessary to study new vinblastine analogues with strong ...