The NIA said it started its misconduct review process in May 2023 at the request of the Office of Research Integrity, which ...

Michael Belloy at Washington University in St. Louis noted that the findings could help distinguish between genes that directly affect pathology, and those that instead help maintain cognition in the ...

For example, Huntington’s disease (HD), the first expansion disorder discovered, occurs when a cysteine-arginine-guanine (CAG) trinucleotide in the HTT gene swells to 40 or more repeats. Such ...

Two of the groups reported that cultured human oligodendrocytes make as much or more Aβ than do neurons, and that ...

The clinical worsening after microglia envelop neurons suggests the phenomenon is harmful, the authors noted. “With disease progression, microglial behavior changes from positive to negative,” ...

A group of scientists argue, in a review published in Fluids and Barriers of the CNS earlier this year, that it’s time to adopt a more apt metaphor. Jan Pieter Konsman and Jerome Badaut of the ...

Frontotemporal dementia (FTD) often strikes our most human traits, such as the ability to speak and to interact on social and emotional levels. Now, research led by Lorenzo Pasquini and William Seeley ...

Scientists are honing transferrin receptors to whisk bulky, anti-Aβ antibodies throughout the brain without setting off ARIA and anemia. By halving the effector function of their antibody transport ...

Now, Meyer and colleagues have found a way to map m 6 A sites that is compatible with single-cell RNA-Seq. They constructed a chimera comprising the cytidine deaminase APOBEC1 and the YTH binding ...