Tissue engineering enables the generation of functional human cardiac tissue with cells derived in vitro in combination with biocompatible materials. Human-induced pluripotent stem cell-derived ...

To determine the role of endothelium-mediated flow-dependent coronary dilatation in humans, we studied the coronary dilatation exerted by maximal pharmacologic increase of coronary flow in 14 patient ...

From the Duke Clinical Research Institute, Duke University Medical Center, Durham, NC (R.M., A.Y.C., L.T., T.Y.W., K.L.T., M.T.R., E.D.P.); and National Heart Centre ...

From the Cardiology Branch, National Heart Institute, Bethesda, Maryland. The circulatory effects of blocking the beta adrenergic receptors with Nethalide were studied in 10 patients with hypertrophic ...

Background— For the majority of cases, the cause of spontaneous aortic dissection and rupture is unknown. An inherited risk is associated with Marfan syndrome, Ehlers-Danlos syndrome type IV, and loci ...

From the Divisions of Clinical Epidemiology, McGill University Health Center, Montreal, Quebec, Canada (M.A.T., E.R., H.B., L.P.); Department of Pharmacy Practice and ...

Background— Ticagrelor is the first reversibly binding oral P2Y12 receptor antagonist. This is the first study to compare the onset and offset of platelet inhibition (IPA) with ticagrelor using the P ...

From the Rush Heart Institute Center for Pulmonary Heart Disease, Rush Medical College, Chicago, Ill. The endothelin (ET) system is comprised of 4 active ETs, with ET-1 being the predominant isoform ...

Long-term effects of workplace sedentary behavior interventions on cardiometabolic risk are poorly understood. Stand and Move at Work was a multi-site group randomized trial in 24 worksites (N=630, 74 ...

The Editors of Circulation: Cardiovascular Quality and Outcomes are pleased to announce a new Patient or Caregiver Viewpoint section in the Journal. Viewpoints will be authored by patients or their ...

Division of Cardiology, Kumamoto University Medical School, Japan.

Pregnancy is a dynamic process associated with significant physiological changes in the cardiovascular system. These changes are mechanisms that the body has adapted to meet the increased metabolic ...