Pathway-focused metabolite ratio-based analysis of 49 tumor and 8 normal epithelial cell lines grown in their respective ...

Global regulation of secondary metabolism gene clusters is achieved by globally acting transcription factors, which are encoded by genes that do not belong to any cluster. Pathway-specific ...

Enzyme kinetic data from the BRENDA database were mapped onto the genome-scale metabolic model of Saccharomyces cerevisiae to ...

Secondary metabolites are compounds produced by an ... arise from the amino acid tyrosine in an irreversible pathway. In addition, biochemical laws necessitate all precursors of catecholamine ...

Secondary metabolites (SMs), as the main active components ... thereby stimulating the expression of genes related to metabolic pathways. Conversely, SMs synthesized by some medicinal plants ...

These data are then compared across groups using an appropriate statistical analysis. In some cases, a pathway specific metabolite that is found to be differentially abundance will be further studied ...

Diosgenin, a secondary metabolite isolated from the Dioscorea ... Diosgenin and brassinosteroids share similar structures and biosynthetic pathways, yet the regulatory networks of diosgenin ...

We also aim at dissecting the biosynthetic pathways leading to Asteraceae specific secondary metabolites.

Unfortunately, detecting coresponses between transcript levels and metabolite abundances is non-trivial: they cannot be assumed to overlap directly with underlying biochemical pathways and they may be ...