Systemic mastocytosis is a disease where too many abnormal mast cells (a type of white blood cell) build up in your skin and other organs. You might get a variety of symptoms, including itchy skin ...

The disease course is highly variable ... 1 Pathogenesis of CSU: The Role of Mast Cells Understanding the role of mast cells is key to grasping the underlying mechanisms of CSU.

Jasper Therapeutics, Inc. (Nasdaq: JSPR) (Jasper), a clinical stage biotechnology company focused on development of briquilimab, a novel antibody therapy targeting c-Kit to address mast cell driven ...

underscoring the importance of treating patients early in the ISM disease course -- -- BLU-808 healthy volunteer trial results demonstrate wide therapeutic window for modulating mast cell activity ...

The past year has been a transformational period for Jasper, highlighted by positive data readouts from the BEACON study in CSU and the ...

Jasper expects to report data around mid-year 2025 from 4 cohorts: the 240mg single dose cohort (4 additional patients), 240mg Q8W cohort (8 patients), 240mg followed by 180mg Q8W cohort (8 patients), ...

For example, since we entered the SM space, more than 20 advocacy groups worldwide have come together to launch the International Mastocytosis and Mast Cell Diseases Awareness Day, which is ...

Updated data show AYVAKIT® (avapritinib) was safe and effective for long-term treatment of ISM, with sustained symptom and quality-of-life bene ...

Systemic mastocytosis (SM) is a rare disease driven by the KIT D816V mutation in about 95 percent of cases. Uncontrolled proliferation and activation of mast cells result in chronic, severe and ...