Figure 1: Cryo-EM structure ... strand. RNA separates at the upstream end of the hybrid and passes beneath the lid loop through the proposed RNA exit tunnel to reach the Pol II surface near ...

To initiate gene transcription, RNA polymerase II (Pol II) requires the transcription factor IIB (B). Here we present the crystal structure of the complete Pol II–B complex at 4.3 Å ...

TFIID enables RNA polymerase II promoter-proximal pausing. Mol Cell 2020, 78: 785 – 793. Schier, AC; Taatjes, DJ. Structure and mechanism of the RNA polymerase II transcription machinery. Genes Dev.

An RNA polymerase II molecule is about 15 nanometers across, or roughly 5,000 times smaller than the width of a human hair. This image was created by reconstructing X-ray diffraction crystallography ...

RNA polymerase Pol II is one out of three different RNA polymerases used by ... the carboxy-terminal part of the largest subunit of Pol II, which has a very unique structure. Never miss a story ...

RNAP II is the enzyme primarily responsible for the synthesis of messenger RNA (mRNA). RNAP I and III contain an extra heterodimeric subunit. RNAP III alone has a heterotrimeric subunit ...

RNA polymerase II 3 transcribes protein-coding genes into messenger RNA (mRNA). This 12-subunit enzyme works as a complex that directly influences gene expression through its production of pre-mRNA ...

A team in China led by Zihe Rao at Tsinghua University report the cryo-electron microscopy (cryo-EM) structure of the RNA-dependent RNA polymerase (RdRp), which is a key part of the virus’s ...

While RNA polymerase II was known to be critical in ensuring the accuracy of transcription, it had been a long-standing puzzle as to how this enzyme accomplishes this difficult task. Scientists ...

For the first time, researchers have visualized the three-dimensional structure of the Nipah virus's RNA polymerase—the ...

This enables the RNA polymerase (RNAP ... and due to their simple genetic structure, they provided the team with an ideal ...

New research by German scientists has uncovered another form of coronavirus polymerase ... enzymes may keep working in the dimer structure, continuing RNA-dependent processes — although the ...