View Full Profile. Learn about our Editorial Policies. Rational design is the classical protein engineering method that involves site directed mutagenesis. 7 Scientists perform specific point ...

AI systems already work their magic in many areas of biomedical science, helping to solve protein structure, discover hidden ...

Functional protein design, particularly for proteins binding to small molecules such as enzymes and biosensors, is crucial for drug discovery and biomedical applications. Traditional methods based ...

LigandMPNN is a deep-learning-based protein sequence design method that can explicitly model all nonprotein components of biomolecular systems. Protein nanocages are multimeric molecular ...

A new set of artificial intelligence models could make protein sequencing even more powerful for better understanding cell biology and diseases.

In living organisms, every protein—a type of biological polymer consisting of hundreds of amino acids—carries out specific ...

While AlphaFold and the subsequent AI revolution in biology garnered a lot of attention, the foundational bricks for the strides made in protein structure and design today were laid ... we could use ...

A previously unknown protein in a family of bacteria found in soil and the human gut microbiome has been discovered—which ...

In the current study, the researchers used what is known as fragment-based drug design instead. The method involves first identifying a very small molecule that can bind to the target protein.

Shanghai scientists have made breakthrough in protein design by leveraging artificial intelligence, establishing the world's ...

In this method, the cell extract or culture medium is passed through a chromatography column filled with a porous carrier material. The target protein is bound to this carrier material and ...