Researchers have discovered the first protein quality control system in the yeast nucleus. They report that the system involves an ubiquitin-protein ligase that specifically targets four distinct ...

To test this idea, they engineered an artificial way to secure rDNA to the membrane surrounding the nucleus of yeast cells so they could control when it was anchored and when it was not.

By taking yeast cells and rebuilding their genomes ... had been done on prokaryotes (single-celled organisms that lack a nucleus), but a full synthetic genome had not been reconstructed for ...

Gene regulation underpins nearly every biological process—from cell development to responses to environmental changes, and understanding it can provide insights into cancer and other diseases. Now, ...

. Published by Oxford University Press 198 Madison Avenue, New York, New York 10016, USA; 1997. pp. 360. $45.00 Whereas the yeast Saccharomyces cerevisiae has been the preferred tool for many ...

However, the yeast two-hybrid system is limited to studying proteins that can translocate to the nucleus and do not display any autonomous capacity for activating transcription 2. Thus ...