Scientists have engineered a chromosome entirely from scratch that will contribute to the production of the world’s first synthetic yeast. Researchers in the Manchester Institute of Biotechnology (MIB ...

To tackle the conundrum, Yingjin Yuan, a professor of biochemical engineering at Tianjin University, turned to deoxyribonucleic acid (DNA) and has designed yeast artificial chromosomes as a ...

Initially, the chromosome was synthesized in segments called megachunks, which were then cloned into vectors and integrated into yeast strains through homologous recombination. Each megachunk ...

Instead of the linear chromosomes found in mammals, the team crafted a circular chromosome, which is compatible with DNA replication in yeast. They then assembled the HAC inside budding yeast. By ...