The research team used specialized gene editing tools to identify and fix problems in the synthetic chromosome affecting how well the yeast could reproduce and grow under challenging conditions.

Initially, the chromosome was synthesized in segments called megachunks, which were then cloned into vectors and integrated into yeast strains through homologous recombination. Each megachunk ...

Scientists have engineered a chromosome entirely from scratch that will contribute to the production of the world’s first synthetic yeast. Researchers in the Manchester Institute of Biotechnology (MIB ...

Instead of the linear chromosomes found in mammals, the team crafted a circular chromosome, which is compatible with DNA replication in yeast. They then assembled the HAC inside budding yeast. By ...

To tackle the conundrum, Yingjin Yuan, a professor of biochemical engineering at Tianjin University, turned to deoxyribonucleic acid (DNA) and has designed yeast artificial chromosomes as a ...

Researchers have generated a full-length clone of the novel coronavirus genome using artificial chromosomes in brewers’ yeast, according to a paper published in Nature on Monday (May 4). While other ...

B. Interactions between chromosomes, dependent on ZMM proteins in yeast, feed back to inhibit Spo11. C. DSB formation is temporspatially coordinated with DNA replication. D. Activation of Ndt80 ...

In yeast, however, binding of Rad51 to ssDNA ... An alternate hypothesis proposes that homologous chromosomes reside in pairs constitutively. Acting against this hypothesis is the finding that ...

I thought there had to be more to it. In yeast, chromosome instability causes the organism to die. So how can damaged DNA be enough to cause cancer? I then began testing whether or not this dogma was ...