Wolverine was poisoned and this ties into the initial threat from the opening. Someone is hunting down adamantium. This also plays into the trope of taking out a heavy hitter early in order to ...

Hunting caused the species to disappear from ... Despite recent population growth, the wolverine's survival remains threatened by its small population size, low genetic viability, and fragmented ...

Wolverine and Predator vs ... Having claimed Wakanda's vibranium and turned Earth into a hunting preserve, a Predator King will begin hunting Earth's heroes and villains en masse.

It’s a simple story, with each issue focusing on Wolverine hunting down his foes, and it’s all the better for it.