Gilead Sciences announced a significant milestone: the U.S. FDA accepted their New Drug Applications (NDAs) for lenacapavir ...

To become infectious, HIV has to undergo a maturation process, which involves a rearrangement of the matrix proteins (red). In an immature virus particle, the matrix proteins form a lose lattice ...

Infections with the hepatitis E virus often go unnoticed because they cause no symptoms. However, in patients with a weakened ...

The basic components of a virus are genetic material and a protein shell, called a capsid, that surrounds and protects the fragile nucleic acids. During the life cycle of a virus, the genetic material ...

Using the vertical β-barrel major capsid proteins and ATPases related to known viral genome-packaging ATPases as examples, we can now re-evaluate the classification of viruses and virus-like ...

Local Rule-Based Theory of Virus Shell Assembly. Proceedings of the National Academy of Sciences of the United States of America, 1994. 91(16): p. 7732-7736. Elrad, O. M. and M.F. Hagan, Mechanisms of ...

Toroidal vortices, common in fluid dynamics, are newly explored in electromagnetism as two distinct forms: vector toroidal ...

Supercomputer simulations have revealed how changes in the shape of the HIV-1 capsid protein may help the virus squeeze its inner core into the host cell's nuclear membrane. The findings ...

The dengue virus has a roughly spherical structure. It is composed of the viral genome and capsid proteins surrounded by an envelope and a shell of proteins. After infecting a host cell ...

The virus is composed of three layers—a capsid that contains the viral DNA, a protein layer called the tegument and an outer envelope that is studded with viral glycoproteins (proteins with a ...

Unlike traditional antiretrovirals that target enzymes such as reverse transcriptase or protease, LEN binds directly to the capsid protein, disrupting several critical steps in the virus’s life ...