These toxins block exocytosis (the process of secretion, involving fusion of the transport vesicle with the plasma membrane) by proteolysis of one or another of the presynaptic SNARE molecules ...

The role of ITSN1, Intersectin-1, is to activate CDC42, a small Rho GTPase involved in the growth and maintenance of dopaminergic neurons and the regulation of vesicle exocytosis of α-synuclein ...

It reveals a pore complex with extended arms that could bind receptors involved in synaptic vesicle exocytosis. Perhaps these multiple actions are needed to cover the diversity of targets ...

"Until our collaborative study, exocyst was understood to recognize and possibly tether secretory vesicles to the cell membrane, prior to exocytosis. In this study, we reveal biophysical studies ...

Our team has conducted the first genome-wide CRISPR screens to systematically identify new regulators of regulated exocytosis—a type of vesicle fusion—in mammalian cells. These screens revealed a ...