Here’s how it works. Valproic acid — a drug commonly used to treat epilepsy and bipolar disorder — can cause birth defects and developmental disorders if taken during pregnancy, but the ...

The use of valproic acid in the first trimester of pregnancy is associated with an increased risk of spina bifida, but data on the risks of other congenital malformations are limited. We first ...

Childhood absence epilepsy, the most common pediatric epilepsy syndrome, is usually treated with ethosuximide, valproic acid, or lamotrigine. The most efficacious and tolerable initial empirical ...

Valproic acid dissociates to form valproate ions in the body, which has numerous effects on the neuronal tissue in the brain. This accounts for its broad clinical activity and uses in several ...

Divalproex ER administered once daily had less fluctuation in valproic acid concentrations, i.e. divalproex ER achieved equal or significantly higher minimum concentrations and significantly lower ...

The FDA has endorsed plans for a Phase 2b clinical trial that will test CS1, Cereno Scientific's experimental treatment for PAH.

Valproic acid is an antiepileptic drug that is commonly used in conjunction with other pharmaceutical therapies, which has the potential to lead to interactions between the drugs. This occurs ...

Feb. 6, 2004 — Valproic acid has no effect on pain in polyneuropathy, according to the results of a randomized, double-blind, placebo-controlled study published in the Jan. 27 issue of Neurology.

Valproic acid dissociates to the valproate ion in the GI tract. The mechanisms by which valproate exerts its therapeutic effects have not been established. It has been suggested that its activity ...