In summary, we have demonstrated a new approach to the investigation and targeting of T cell malignancies through distinguishing between two possible TCR β-chain constant regions. Using CAR T ...

1-3 Adoptive cell therapy with the use of T cells that have been engineered to express allogeneic T-cell receptors (TCRs ... mouse TCRα and TCRβ constant regions, which promoted the pairing ...

According to new research, T cells have a nuclear receptor ... RARα belongs to a large family of retinoic acid receptors that normally sit on control regions of target genes in the nucleus.

A patient with recurrent multifocal glioblastoma received chimeric antigen receptor ... CAR T cells were delivered through a Rickham catheter device into the right temporal–occipital region ...

A study has demonstrated the potential of a novel ligand-based CAR T-cell therapy for targeting CD7-positive T-cell malignancies, including T-cell acute lymphoblastic leukemia (T-ALL) and T-cell ...

The engineered high-affinity TCR with amino acid substitutions lead to T-cell activation and cancer cell death. lete-cel, letetresgene autoleucel; MHC, major histocompatibility complex; TCR, T-cell ...

Giving an additional receptor to T cells that might already be ... Scientists might be inspired, for instance, to design cells to ferry unique payloads to regions or cells in the body such as ...