are certainly of interest but do not yet provide an informative tool useful in the screening of inhibitors ... steps (ubiquitin tagging, unfolding, and proteolysis) of the ubiquitin/proteasome ...

Researchers from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences constructed a ...

We are mainly interested in two SCF type of ubiquitin ligases (SCFSkp2 and SCFFbx4; Zeng et al. 2010). More recently we developed high throughput screening assays for identifying small molecule ...

Despite advancements in melanoma therapy, the prognosis remains unfavorable for many patients. The proteasome inhibitor MG132 has shown therapeutic potential through pathway regulation, yet its ...

A new review published in Genes & Diseases explores the pivotal role of the ubiquitin-proteasome system (UPS ... finding for ...

If you are a molecular or cell biologist, chances are that at some stage you will encounter some aspect of the ubiquitin ... proteasome system affects practically every cellular process. Its ...