We believe that the ubiquitin/proteasome pathway is involved in so many cellular processes that it could not be properly described by a single model substrate and that the minimal requirement ...

The work has led to a new class of therapeutic targets associated with the ubiquitin-proteasome pathway that offers the potential for treatment of cachexia (also known as muscle atrophy) and other ...

The proteasome is a large protein complex in the cytoplasm of eukaryotic and archaeal cells responsible for proteolysis of proteins that have one or more poly-ubiquitin post-translational ...

influence various cell death pathways crucial to cancer progression and treatment response. The intricate ubiquitin-proteasome system (UPS) plays a vital role in maintaining cellular homeostasis ...

Published in Genes & Diseases, this article explores the intricate mechanisms through which the ubiquitin (Ub) system ...