Following the discovery of ubiquitin in the late 1970s and the delineation of the enzymology of the pathway ... complexities of how substrates are targeted to the 26S proteasome, and the ...

Posttranslational modifications can regulate the activity of proteins and their interaction patterns ... The 76 amino acid ubiquitin is best known for its role in the ubiquitin-proteasome pathway for ...

Tobacco-based products, including e-cigarettes, have gained popularity as perceived safer alternatives to traditional smoking despite their addictive nature. However, emerging evidence shows that ...